It seems Marvel has a new promotional image asking, "Who are the Mystery Men?" with nothing else to go with the cryptic phrase but a release date of June 2011 and this image:
Some part of me hopes this relates to the MIA series, "The Twelve" but the odds of that are about .1%. The reason such a thought even entered my mind was the old-timey look of the image. It is as if this takes place in the past with some sort of super-team. My money is on something that isn't quite an event like Fear Itself, but more likely a new alternate continuity series like the Noir comics Marvel put out. I could be horribly wrong, but that's just my guess.